产品货号：
Z29840
中文名称：
XRCC1抗体
英文名称：
Anti-XRCC1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-XRCC1 Antibody |
| 指标别名 | DNA repair protein XRCC1;RCC;XRCC1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC |
| 基因名称 | XRCC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human XRCC1(15-34aa QDSTHCAENLLKADTYRKWR),identical to the related mouse sequence,and different from the related rat sequence by one amino acid. |
| 实际分子量 | 80～90KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | XRCC1(X-RAY REPAIR,COMPLEMENTING DEFECTIVE,IN CHINESE HAMSTER,1) is a DNA repair protein which complexes with DNA ligase III.The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents.The XRCC1 gene is mapped to 19q13.31.The XRCC1 interacts with DNA ligase III,polymerase beta and poly(ADP-ribose) polymerase to participate in the base excision repair pathway.It may play a role in DNA processing during meiogenesis and recombination in germ cells.A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.XRCC1 is phosphorylated in vivo and in vitro by CK2,and CK2 phosphorylation of XRCC1 on ser518,thr519,and thr523 largely determines aprataxin binding to XRCC1 through its FHA domain. |
| Uniprot ID | P18887 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | X-ray repair complementing defective repair in Chinese hamster cells 1 |
| 蛋白名全称 | DNA repair protein XRCC1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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